Getting my 90 year old Dad off Oxy, and on CBD

Study Finds Medical Cannabis Safe for Managing Pain in Elderly Patients

After six months, medical cannabis significantly improved pain and quality of life for older adults with minimal side effects. More than 93 percent of 901 participants reported their pain dropped from eight to four on the 10-point scale. Quality of life upgraded from “bad” or “very bad” to “good” or “very good” in approximately 60 percent of patients. More than 70 percent of patients reported experiencing moderate to significant improvement in their condition.

Safety and Efficacy of Medical Cannabis in Elderly Patients

[Medical Cannabis] is a well-tolerated treatment with improvement noted in chronic pain, sleep, neuropathy, and anxiety in patients ≥75 years of age.  [Adverse effects] that resolved on dosage adjustment were noted in 13% of patients.

Friends, to my great delight, my mother has finally become willing to pursue use of CBD to replace the heroin (Oxycontin) my beloved (soon to be) 90 year old Dad has been taking for years, after a herniated disk caused chronic pain.

Mom told me last week that my Dad was ‘slowing down at an alarming rate’, which broke my heart. Later that day, it hit me like a lighting bolt out of nowhere: IT’S THE OXY! Of course there will be decline in old age, but heroin will take down a 20 year old in no time, what is it doing to our parents? 

I’ve compiled a bunch of information for my Mom to share with her doctor to get approval, and found a couple options from a local CBD shop to begin our journey. Please enjoy:
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Study Finds Bees Don’t Just Love Cannabis — it Can Also Help Save Their Dying Populations

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Shamani Joshi

Humans aren’t the only ones who seem to gravitate towards the marijuana plant. Turns out, even bees love the buzz, but for a slightly different reason. A new study by researchers at Cornell University published in the journal of Environmental Entomology finds that bees are super attracted to the cannabis plants because they can’t get enough of its sweet, sweet pollen. This study supports the results of a similar one conducted by Colorado University last year and opens up options for scientists to save the depleting bee population around the world.

The study found that the taller the cannabis plants are and the larger area they cover, the more bees will flock to that farm, with taller plants attracting 17 times more buzz than the shorter ones. What’s even cooler is that there are 16 different varieties of the marijuana plant that could support these bee populations. But even as bees seem to love the cannabis plant, they can’t actually get high off it since insects aren’t known to have any cannabinoid receptors.

These findings are kinda confusing when you consider that cannabis neither has a nectary taste nor the vibrant colours that generally catch the attention of bees. However, the bees are more into the male plants that usually grow alongside the flowering female ones that produce the bud you put into your bongs, but have no psychoactive properties. This study is especially crucial given that bees are responsible for the cross-pollination of flowers that furthers the growth of the fruits and vegetables we need for survival. Except, thanks to pesticides, habit destruction and climate change, the bees seem to be buzzing off, something that the marijuana plant could help put a stop to since they also don’t generally use too many pesticides, nor require too much water for their growth.

But what’s even better about these canna-bees is that they bring with them immense industrial potential. Israeli cannabis technology company PhytoPharma International developed a natural cannabinoid-dosed honey that allows bees to fuse THC and CBD into their honey by an IP-protected pollination process. Now if that’s not worth the buzz, we don’t know what is.

New Canadian Study Says Marijuana May Prevent The Coronavirus

According to a study being conducted at Canada’s University of Lethbridge, scientists are now theorizing that certain marijuana strains could possibly prevent COVID-19 infection.Researchers at the Calgary college have studied over 400 strains of weed and have concluded that at least a dozen strains aided in preventing the Coronavirus from finding a host in the mouth, intestines, and lungs.The study’s head researcher Dr. Igor Kovalchuk said, “A number of them have reduced the number of these (virus) receptors by 73 percent, the chance of it getting in is much lower. If they can reduce the number of receptors, there’s much less chance of getting infected.”

Researchers were able to identify 13 CBD extracts that are able to change ACE2 levels, an enzyme previously linked to COVID-19 infection. The data also suggested that some strains were also able to control serine protease TMPRSS2, which is another protein necessary for COVID-19 to enter host cells and spread throughout the body.

If peer-reviewed and more research is actually done on the subject, the study could be performed in the form of mouth wash, gargle, inhalants or gel caps, according to Kovalchuk.

from the source

Here is the abstract from the study

With the rapidly growing pandemic of COVID-19 caused by the new and challenging to treat zoonotic SARS-CoV2 coronavirus, there is an urgent need for new therapies and prevention strategies that can help curtail disease spread and reduce mortality. Inhibition of viral entry and thereby spread constitute plausible therapeutic avenues. Similar to other respiratory pathogens, SARS-CoV2 is transmitted through respiratory droplets, with potential for aerosol and contact spread. It uses receptor-mediated entry into the human host via angiotensin-converting enzyme II (ACE2) that is expressed in lung tissue, as well as oral and nasal mucosa, kidney, testes, and the gastrointestinal tract. Modulation of ACE2 levels in these gateway tissues may prove a plausible strategy for decreasing disease susceptibility. Cannabis sativa, especially one high in the anti-inflammatory cannabinoid cannabidiol (CBD), has been proposed to modulate gene expression and inflammation and harbour anti-cancer and anti-inflammatory properties. Working under the Health Canada research license, we have developed over 800 new Cannabis sativa lines and extracts and hypothesized that high-CBD C. sativa extracts may be used to modulate ACE2 expression in COVID-19 target tissues. Screening C. sativa extracts using artificial human 3D models of oral, airway, and intestinal tissues, we identified 13 high CBD C. sativa extracts that modulate ACE2 gene expression and ACE2 protein levels. Our initial data suggest that some C. sativa extract down-regulate serine protease TMPRSS2, another critical protein required for SARS-CoV2 entry into host cells. While our most effective extracts require further large-scale validation, our study is crucial for the future analysis of the effects of medical cannabis on COVID-19. The extracts of our most successful and novel high CBD C. sativa lines, pending further investigation, may become a useful and safe addition to the treatment of COVID-19 as an adjunct therapy. They can be used to develop easy-to-use preventative treatments in the form of mouthwash and throat gargle products for both clinical and at-home use. Such products ought to be tested for their potential to decrease viral entry via the oral mucosa. Given the current dire and rapidly evolving epidemiological situation, every possible therapeutic opportunity and avenue must be considered.

Cannabis and Corona Virus: What Do We Know So Far?

There is ongoing research into medicinal cannabis for treatment of coronavirus

But what do we know thus far?

From Project CBD:

Given the conflicting data on the impact of cannabinioids on immune function, medical scientists are reevaluating their ideas about inflammation and immunosuppression. As Mary Biles reported for Project CBD: “A new wave of research and mounting anecdotal evidence points towards cannabinoids having an adaptive, immunomodulating effect, rather than just suppressing immune activity.”

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Cannabis & the Immune System: A Complex Balancing Act

A new wave of research points toward cannabinoids having an adaptive, immunomodulating effect.

Cannabis sativa has been consumed for health and nutritional purposes for thousands of years. Many ancient civilizations – from the Chinese to the Greeks – included cannabis in their pharmacopoeia. Back then, no one questioned how or why cannabis relieved pain and calmed the spirits. It was a helpful ally – that’s all that mattered.

Fast forward to the 21st century. Scientists are trying to understand not only the molecular makeup of cannabis, but also how it interacts with the complex web of biological systems in our bodies. Yet, despite many exciting discoveries, we still know relatively little, especially when it comes to the interplay between cannabis and the immune system.

Some studies suggest that cannabinoids like THC and CBD are immunosuppressant, which can explain the relief experienced by medical cannabis users with autoimmune diseases and chronic inflammation. Other studies have shown that regular cannabis use can increase white blood cell counts in immunodeficiency disorders such as HIV, suggesting an immune-boosting effect.

It gets even more complicated when we consider that the effects of cannabis are mediated primarily by the endocannabinoid system, which scientists believe interacts with all biological activity, including our immune system.

The bottom line is that much remains to be discovered about how cannabis affects our immune system. Here’s some of what we know so far.

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