Sometime next week medicalmarijuana.com.au will have the honour of interviewing the esteemed molecular biologist Dr Cristina Sánchez PhD.
Dr Sanchez has devoted the past 10 years to cannabinoid research, and most recently ” new cannabinoid receptors and their possible involvement in cannabinoid antitumoral action in breast cancer and other type of tumors.”
Now with this honour comes great responsibility! What do I ask a such an educated person on the subject of medical cannabis?
Then my friend Dennis Hill came to mind. I put the question to Dennis and he quickly replied with these two pertinent questions: (Thanks Dennis)
Question 1;
We know that CBD inhibits the mental effects of THC, but does this action also inhibit any of the therapeutic capabilities of THC? Do you know the mechanism of how CBD inhibits the mental effects of THC?
Question 2;
Please explain the entourage effect of how phytocannabinoids and other cannabis enzymes work cooperatively to efficiently and effectively treat cancer?
So now I have two great questions for Cristina, but I want more!
Hence, I’m giving you bloggers and supporters of Patients for Medical Cannabis the opportunity to ask Dr Cristina Sánchez a question related to her research. No guarantees the questions will be used, but all questions are much appreciated.
Please email steve@medicalmarijuana.com.au before 19/7/15 or 7/19/15 ….. by next Sunday.
About Dr Cristina Sánchez;
Cristina Sánchez (Madrid, Spain, 1971) graduated in Biology at Madrid Complutense University in 1994.
She started her scientific career as an undergraduate student at the laboratory of Dr. Ramos and Dr. Fernández Ruiz (School of Medicine, Complutense University), where she first took contact with the field of cannabinoid research. Once graduated, she moved to Dr. Guzmán’s laboratory (School of Biology, Complutense University), where she studied the effect of cannabinoids on lipid and carbohydrate intermediate metabolism first and on cancer cell proliferation later. She obtained her PhD with Honors in Biochemistry and Molecular Biology at Complutense University in 2000.
During her postdoc at Dr. Piomelli’s laboratory (University of California Irvine, 20002003) she studied the involvement of another group of bioactive lipids (lysophosphatidic acid and related compounds) on pain initiation.
In 2004, Cristina returned to Spain with a “Ramón y Cajal” contract (aimed at repatriating Spanish researchers from abroad) and she started coordinating a new line of research within Dr. Guzmán’s laboratory. In particular, the goal of her research is to understand and exploit cannabinoids as potential antitumoral agents in breast cancer. More recently, she has also focused her attention on new cannabinoid receptors and their possible involvement in cannabinoid antitumoral action in breast cancer and other type of tumors.
reference: http://www.bbm1.ucm.es/cannabis/cristinasanchezinicio_en.htm
recent publications Dr Cristina Sánchez has been involved with can be viewed here:
http://www.bbm1.ucm.es/cannabis/publicaciones_en.htm
Patients for Medical Cannabis 
How does it work as an anti-biotic against MRSA?
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Thanks for the question Fumes, good one.
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I especially like Dr. Sanchez’ thought that everyone is different, and every cancer is different, thus we must be very careful so that each patient gets whatever ratio of cannabinoids is appropriate to that person’s healing. Another good point is that not all disorders require cannabinoids to bind to a receptor. The entourage of cannabis therapeutics can be effective with and without receptor activity.
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Hi–I was wondering if the question was ever posed about whether the wrong ratio could actually encourage metastasis? Did the doctor ever find instances where too much thc seemed to spread the cancer, specifically estrogen positive breast cancers? I have read that higher thc ratios have this negative effect on certain breast cancers but I’m having trouble finding evidence of this either in preclinical studies or anecdotally. Thank you.
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Jean – We know that CBD inhibits the Id-1 gene that promotes metastasis. The literature often reports that women with breast cancer do better with predominant CBD over THC. But I have not seen any reports that THC causes metastasis. If breast cancer is treated only with THC, cancer is killed through the CB1 receptor, but there is little inhibition of metastasis in breast cancer. There is one report that says that if too much THC is used in estrogen positive breast cancer, that the cancer will grow. But no mention of metastatic lesions: http://www.unitedpatientsgroup.com/blog/2015/06/02/treating-breast-cancer-with-cannabis-why-the-treatment-must-match-the-classification/
~Dennis
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