Cannabis Promotes Healthy Bone Metabolism

Excerpt and image from Halcion Organics

A 2010 experimental study concluded that cannabinoids may be an effective treatment for multifaceted bone diseases like osteoporosis.  This was an in vivo study performed on mice.  At a clinical level, humans and mice have a lot in common!

This study determined that endocannabinoids and their receptors are involved in the pathogenesis of osteoporosis.  It found that pharmacological and genetic inactivation of the CB1, CB2, and GPR55 receptors in adult mice increase bone mass, suppress bone resorption, and protect against bone loss.  This means that CB1 and CB2 agonists and antagonists may prevent or even reverse the pathology of osteoporosis and other bone diseases.

Here are the two studies that were referenced in this article.

Cannabinoid Receptors as Target for Treatment of Osteoporosis

Endocannabinoids regulate bone metabolism


CBD may therefore recruit MSCs to sites of calcifying tissue regeneration and subsequently support bone regeneration via an osteoanabolic action on MSCs.

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