New research suggests cannabis could help reverse aging process in the brain

Abstract from Nature Medicine

The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes underlying aging1, 2. The activity of the ECS declines during aging, as CB1 receptor expression and coupling to G proteins are reduced in the brain tissues of older animals3, 4, 5 and the levels of the major endocannabinoid 2-arachidonoylglycerol (2-AG) are lower6. However, a direct link between endocannabinoid tone and aging symptoms has not been demonstrated. Here we show that a low dose of Δ9-tetrahydrocannabinol (THC) reversed the age-related decline in cognitive performance of mice aged 12 and 18 months. This behavioral effect was accompanied by enhanced expression of synaptic marker proteins and increased hippocampal spine density. THC treatment restored hippocampal gene transcription patterns such that the expression profiles of THC-treated mice aged 12 months closely resembled those of THC-free animals aged 2 months. The transcriptional effects of THC were critically dependent on glutamatergic CB1 receptors and histone acetylation, as their inhibition blocked the beneficial effects of THC. Thus, restoration of CB1 signaling in old individuals could be an effective strategy to treat age-related cognitive impairments.

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In this Sept. 30, 2016, file photo, a harvester examines marijuana buds from a trimming machine near Corvallis, Ore. THE CANADIAN PRESS/AP Photo/Andrew Selsky

From CTVNews Published Tuesday, May 9, 2017 7:01PM EDT

New European research on animals suggests that cannabis could help reverse the aging process in the brain, opening up the possibility that the drug could be used in the treatment of dementia.

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One thought on “New research suggests cannabis could help reverse aging process in the brain

  1. In what form was the THC given to the mice? I don’t suppose they were smoking it. lol Although mice were once forced to breathe marijuana smoke without enough oxygen, to falsely prove that marijuana harms the brain. Also note that it is specifically THC that rejuvenates the brain, not CBD, which has many other medical benefits.

    Liked by 1 person

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