Dennis Hill: Understanding and Preventing cancer with Cannabinoids & the Endocannabinoid System

We have answered the question, What cures all cancer?… Cannabis therapeutics.
Now I have another question; What is the cause of all cancer? Show me the science.
Today we know the cause of all cancer… sugar.  And today we have the science.

Scientists reveal the relationship between sugar, cancer
A nine-year joint research project has led to a crucial breakthrough in cancer research. Scientists have clarified how the Warburg effect, a phenomenon in which cancer cells rapidly break down sugars, stimulates tumor growth. This discovery provides evidence for a positive correlation between sugar and cancer, which may have far-reaching impacts on tailor-made diets for cancer patients. 

We are talking about the cause within the cell; not the external causes like Glyphosate, sunlight, testosterone, etc. Within the cell there is one cause of accelerated growth: sugar.

How It Works

There is a plentiful supply of research articles and personal testaments that show the efficacy of cannabis effecting cancer remission. However, only a few point to the mechanism by which the cancer cells die. To understand this better we need to know what metabolic processes provide life to the cells.

There are two structures in most cells that sustain life; one is the mitochondria, and the other is the endoplasmic reticulum. The mitochondria primarily produces adenosine triphosphate (ATP) that provides the necessary energy. The endoplasmic reticulum (ER) is a loosely bound envelope around the cell nucleus that synthesizes metabolites and proteins directed by the nuclear DNA that nourish and sustain the cell.

Let us look first at tetrahydrocannabinol (THC) and observe that THC is a natural fit for the CB1 cannabinoid receptor on the cancer cell surface. When THC hits the receptor, the cell generates ceramide that disrupts the mitochondria, closing off energy for the cell. Disruption of the mitochondria releases cytochrome c and reactive oxygen species into the cytosol, hastening cell death. It is notable that this process is specific to cancer cells. Healthy cells have no reaction to THC at the CB1 receptor. The increase in ceramide also disrupts calcium metabolism in the mitochondria, completing the demise to cell death.

The other cannabinoid we know is effective in killing cancer cells is cannabidiol (CBD). The primary job of CBD in the cancer cell is to disrupt the endoplasmic reticulum through wrecking of the calcium metabolism, pushing calcium into the cytosol. This always results in cell death. Another pathway for CBD to effect cancer cell death is the Caspase Cascade, which breaks down proteins and peptides in the cell. When this happens the cell cannot survive. Again, these processes are specific to cancer cells, no normal cells are affected. To top it all off, CBD disrupts the IL-1 gene, inhibiting growth and spread of the cancer.

The Entourage Effect

The most important concept in cannabis therapeutics is the entourage effect. In this path to healing, multiple agents act to efficiently eliminate cancer cells. We know that THC is more potent when CBD is present (and vice versa). We know that THC and CBD are more potent when terpenes and flavonoids are present. This is called whole plant entourage. We can compare entourage treatment with synthetic single cannabinoids to see the clinical difference. To ensure the most efficient and effective treatment for cancer 1:1 THC:CBD from whole plant is recommended.

-Dennis Hill

Advertisements

3 thoughts on “Dennis Hill: Understanding and Preventing cancer with Cannabinoids & the Endocannabinoid System

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s