Dennis Hill: Understanding and Preventing cancer with Cannabinoids & the Endocannabinoid System

We have answered the question, What cures all cancer?… Cannabis therapeutics.
Now I have another question; What is the cause of all cancer? Show me the science.
Today we know the cause of all cancer… sugar.  And today we have the science.

Scientists reveal the relationship between sugar, cancer
A nine-year joint research project has led to a crucial breakthrough in cancer research. Scientists have clarified how the Warburg effect, a phenomenon in which cancer cells rapidly break down sugars, stimulates tumor growth. This discovery provides evidence for a positive correlation between sugar and cancer, which may have far-reaching impacts on tailor-made diets for cancer patients. 

We are talking about the cause within the cell; not the external causes like Glyphosate, sunlight, testosterone, etc. Within the cell there is one cause of accelerated growth: sugar.

How It Works

There is a plentiful supply of research articles and personal testaments that show the efficacy of cannabis effecting cancer remission. However, only a few point to the mechanism by which the cancer cells die. To understand this better we need to know what metabolic processes provide life to the cells.

There are two structures in most cells that sustain life; one is the mitochondria, and the other is the endoplasmic reticulum. The mitochondria primarily produces adenosine triphosphate (ATP) that provides the necessary energy. The endoplasmic reticulum (ER) is a loosely bound envelope around the cell nucleus that synthesizes metabolites and proteins directed by the nuclear DNA that nourish and sustain the cell.

Let us look first at tetrahydrocannabinol (THC) and observe that THC is a natural fit for the CB1 cannabinoid receptor on the cancer cell surface. When THC hits the receptor, the cell generates ceramide that disrupts the mitochondria, closing off energy for the cell. Disruption of the mitochondria releases cytochrome c and reactive oxygen species into the cytosol, hastening cell death. It is notable that this process is specific to cancer cells. Healthy cells have no reaction to THC at the CB1 receptor. The increase in ceramide also disrupts calcium metabolism in the mitochondria, completing the demise to cell death.

The other cannabinoid we know is effective in killing cancer cells is cannabidiol (CBD). The primary job of CBD in the cancer cell is to disrupt the endoplasmic reticulum through wrecking of the calcium metabolism, pushing calcium into the cytosol. This always results in cell death. Another pathway for CBD to effect cancer cell death is the Caspase Cascade, which breaks down proteins and peptides in the cell. When this happens the cell cannot survive. Again, these processes are specific to cancer cells, no normal cells are affected. To top it all off, CBD disrupts the IL-1 gene, inhibiting growth and spread of the cancer.

The Entourage Effect

The most important concept in cannabis therapeutics is the entourage effect. In this path to healing, multiple agents act to efficiently eliminate cancer cells. We know that THC is more potent when CBD is present (and vice versa). We know that THC and CBD are more potent when terpenes and flavonoids are present. This is called whole plant entourage. We can compare entourage treatment with synthetic single cannabinoids to see the clinical difference. To ensure the most efficient and effective treatment for cancer 1:1 THC:CBD from whole plant is recommended.

-Dennis Hill


12 thoughts on “Dennis Hill: Understanding and Preventing cancer with Cannabinoids & the Endocannabinoid System

  1. Hello! I am on the search for a cure for my father who has stage 4 mesothelioma. He has been through all the regular cancer treatments and is finally open to trying cannabis oil. There is so much info out that it is becoming overwhelming. I have found a medical dispensirary somewhat close to us. They have 2 products that have caught my attention. I was hoping you would look at them and tell me which or if either would help my dad to kill his cancer cells and if so what dose would we start him at? I know RSO protocol you work yourself up to a gram a day eventually. These products come in much smaller quantities. Any help is much appreciated!! Here are the two products.

    Thank you so much for any help you can offer! Bobbi


  2. I would recommend the 1:1 RSO. Start with one cap, then increase up to tolerance. Cannabis kills cancer. Even small amounts of cannabis kills cancer. I started with very small amounts of THC and it worked perfectly. ~Dennis


    • Thank you so much for your reply. Can you tell me if it matters if it’s indica or Sativa dominant? I know Rick Simpson suggest indica dominant. Thank you again!!


    • I’m so sorry for all the questions but truly appreciate your help! In one of your articles I believe you said you suggest oral dosing. Is there a reason you don’t suggest suppositories? Is it true that you can use higher doses with suppositories Because you don’t get the head high? Bobbi


  3. Bobbi – When THC is taken orally, the digestive circulation goes to the liver, which transforms it into 11-hydroxy-THC; that is more potent than than THC. If you don’t wan’t to get high, take it before bed, and just sleep through it. Taking it as a suppository does not go to the liver, it simply dilutes the potency. ~Dennis


  4. Hi Dennis, we have been researching ways to
    Help with pleural mesothelioma , stage 4 metastasis and you have helped answer some questions here. However, was wondering to your knowledge, is there any known supplements or treatments that may be counterProductive and/or interactions with using canabis with any of these other treatments?
    For example: he will be starting a virothearapy trial and they inject the tumors with a virus in hopes to let the virus attack the tumors. Also, One of the supplements called MCP, modified citrus pectin we have him on is supposed to help with the spreading as it takes off the gel substance of the cancer cells to where it helps to not allow the cells to metastasis as easy…
    Just wondering if you have heard any of these things to be counterproductive and/or intersections while using canabis, too?
    Any opinion is helpful! Thank you !


  5. Kristy – I am not familiar with the treatments you mentioned, however, since the body’s own endocannabinoid system makes cannabis for the body all the time (Anandamide, 2-AG); I doubt MCP would not be friendly to the cannabis therapeutics.


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