DMSO Cannabis Topical


Editor’s note: Friends, I think we’ve just discovered something that could catapult Cannabis healing into the next dimension. The question has always been how to best get the medicine to the cells. Also see Nutrients Essential for Integrity of Cannabis

Last night I received an email from a patient who mixed CBD:THC oils (equal parts) with DMSO (click here to order from Amazon), and then put it on topically to heal a spinal cord injury. We will keep you all posted as to how this works, but initial results warranted alerting you all immediately. Patient reports he never felt such an intense response to cannabis, even compared with taking Rick Simpson Oil. He said obviously the DMSO is a potent carrier as there is no other reason such a small amount of cannabinoids would have knocked him out like this did. Potentially those with cancers could be using this mixture to apply directly to problem areas. There is much to learn, so let’s get started! Consider this post to be first in a series.

One word of caution: wash hands and the application site well. This is done to make sure you aren’t introducing anything nasty when using DMSO, which will deliver anything that is on your skin into your body and bloodstream.

Our findings support that THC- and CBD-loaded microparticles could be used as an alternative method of cannabinoid delivery in anticancer therapies.

from Dude Grows dot com

Hey guys! I moved from Colorado to Western Massachusetts last year (Family). I work at a hydro shop and it’s been really awesome to watch MA progress with its Cannabis culture. So I’ve been making Cannabis Topical Balm and I’ve been including DMSO as an ingredient and WOW does it work! DMSO is a polar and non-polar solvent that has transdermal properties, it pulls the balm right into the affected (effected?) area. I think I cured arthritis, and my Mom has been putting it on her cancer radiation wound and her latest biopsy was clean and the wound (which is over a year old) is getting smaller. Everyone I trade or give it to raves about it.

Here is my recipe:
2 oz decarbed cannabis flower (higher cbd the better)
2 oz dried arnica flower (anti inflammatory herb)
5 cups organic coconut oil
Steep for 5 hours or magic butter machine it
While the oil is still warm
Blend in
2 oz local beeswax
2 oz DMSO
It is important to give a disclaimer on the DMSO – it opens up your skin to allow everything that follows it to penetrate. This is a bad thing for things like makeup, Aluminum deodorants, motor oil, etc. This means to wash it off your hands really well after applying it so you don’t draw the next thing you touch into your bloodstream. The bottle of DMSO actually says on the label that it is illegal to market DMSO for it health benefits in any way – which I found humorous that the cannabis is legal in my topical but the DMSO makes it illegal. Anyway – if my math is correct the Balm is less than 5%DMSO so it is very mild in its transdermalness. Hit me back if you have questions or want a sample, I’d love to post a recipe to your page. Spread the word because this topical works 10x better than the ones they sell over the counter I tried in Colorado and those work great. I’m talking healing pain relief for any inflammation. Oh yeah it cured our dachshund of her herniated disc which paralyzed her from the waste and the vets said only $6000 surgery would make her walk again. Thanks,  Chuck McKenrick

From Ball Park Dispensary

What is DMSO? marijuana knowledge

What is DMSO?

Dimethyl sulfoxide, or DMSO, is a by-product of paper making. It comes from a substance found in wood.

DMSO has been used as an industrial solvent since the mid-1800s. From about the mid-20th century, researchers have explored its use as an anti-inflammatory agent. While it can sometimes be found as an oral supplement, its safety is unclear. DMSO is primarily used by applying it to the skin. DMSO is easily absorbed by the skin. It’s sometimes used to increase the body’s absorption of other medications.

Some researchers suggests that DMSO might also be useful for:

  • Reducing pain and inflammation caused by arthritis
  • Treating bladder pain and inflammation
  • Slowing the progression of cancer

DMSO is available without a prescription most often in gel or liquid form. It can be purchased in health food stores, animal feed and seed shops, and on the Internet.

DMSO is used topically to decrease pain and speed the healing of wounds, burns, and muscle and skeletal injuries. DMSO is also used topically to treat painful conditions such as headache, inflammation, osteoarthritis, rheumatoid arthritis, and many many more uses. See More DMSO Uses

Why am I telling you about DMSO?

Our skin contains a large amount of cannabinoid receptors. When cannabis is applied directly to the skin, cannabinoids are absorbed quickly into the affected area without wasting time metabolizing or breaking through the blood/brain barrier. This means that the body can utilize more cannabinoids without the risk of overconsumption.

Because cannabinoids cannot penetrate much past the upper epidermis there is no risk of intoxication unless accompanied by a carrier agent like dimethyl sulfoxide (or oleic acid), which could be used to enhance the penetration into the skin. So if you decide to add DMSO to your topical please be aware that it is a carrier and be careful when administering.

This comment is from a forum on DMSO at Michigan Medical Marijuana dot org

I recently used dmso in conjunction with cannabis and it’s extract. I dont know anything of the science, risks, health claims, or legality. I did this all by myself with permission from me.

1st recent- 1/10th gram of warmed decarb’d oil applied to a small area on hand, then rubbed a few drops of dmso into same area. Near instant effects were felt, later realized from the dmso not the cannabis in this topical…but… about 15 minutes later I was with a full on edible effect. Same negative and positive effects I experience when I consume cannabis extract. this time it peaked in 30 minutes lasted for a couple hours.

next day used dmso alone and felt the warm softening relief again. later same day applied 2/10ths g of cannabis oil and some dmso. Cannabis effects were full on in 20 minutes or so and lasted a solid four and a half hours! hours of the same positive, and same negatives that keep me from eating my herb. a small bandaid preparation would please an edible connoisseur, stuck on an arm. I bet leaving it on longer increases effects? I didnt have any negatives, not even stink from my dmso . it does have an odor, slight garlic maybe, but tolerable and short lived.

next I make a poultice with fresh harvested cut buds and dmso, then a dried one too and compare notes.

Adding ten grams of cannabis oil to a small 3.5 ounce jar of icy hot is what it took for me to feel the cannabis on a diseased joint for thought. I dont know why I didnt experience the same anti inflammatory results with the dmso dosing, but it sure wasnt 10 grams either, and not sure why I didnt feel the cannabis farther away from the application site with the icy hot. Lots of things to try. I’ve met some who use dmso several times a day and said they couldnt walk without it.

I can tell dmso is going to be part of my life from now on. I’ve used it for super rapid vitamin dosing with awesome results. magnesium with it is an instant win on an arthritic joint, swollen anything.

I caution those with dirty hands while using dmso, all the stuff on your hands goes into your blood stream quickly. wash, dry, repeat, carry on if inclined.

A success story from Grass City forum

I want to tell everyone that dmso used as a delivery agent for topical application of cannabis oil works extremely well. I’ve been battling basel cell carcinoma for over a decade. Lesions popping up on my neck, back, legs etc.The dermatologist froze them or cut them out. The lesions that were frozen almost always came back. Having stitches taken out of your back is a pain in the butt as you can’t do it yourself. She wanted to start using a “chemo cream” and the word chemo scared me right off. In 2014 I had a particularly nasty lesion on my leg that was getting painful and I was about to schedule removal when a girl I was dating suggested cannabis oil. I was skeptical but decided to give it a try after a bunch of research. When she popped by with the oil she also had dmso. She explained what it was and how she thought it would help my body absorb the oil more effectively. Again, skeptical, and after some research into dmso I figured why not give it a try. She thought that mixing a little oil in with the dmso would help it stick better because in pure form it just rolled off the lesion. So the application was dmso (mixed with oil) followed by a healthy dollop of oil, covered with a cotton pad and taped over. The first pic shows day 1. The second pic shows day 3. (View photos here) After 2 weeks of applications I didn’t really notice any additional change and lost interest in the experiment. Over the following week (once exposed to air) the lesion dried up, scabbed, then fell off. Two years later there isn’t even a scar. I stopped going to my dermatologist. When I went to a naturopath to apply for a prescription/license I told her that the oil got rid of a major lesion in 3 weeks, she looked skeptically at me and said that normally it should take a month or two. Then I remembered the dmso and told her about it. Her reply was, “very interesting, the dmso is the delivery agent .”

Here is a great 60 Minutes segment on the healing properties of, and controversy surrounding, DMSO

Here is a very informative and insteresting report on the use of DMSO with colloidal silver


19 thoughts on “DMSO Cannabis Topical

  1. This is brilliant !!!

    On Sun, Mar 24, 2019 at 5:27 PM Patients for Medical Cannabis wrote:

    > Admin posted: ” Editor’s note: Friends, I think we’ve just discovered > something that could catapult Cannabis healing into the next dimension. The > question has always been how to best get the medicine to the cells. Last > night I received an email from a patient who mixed” >

    Liked by 1 person

  2. For 4 years I have been using Cannabis Extract or RSO mixed with some extra CBD and then add DMSO in a glass dropper bottle with glass dropper. I have used it to great effect for soreness arising from my Pickleball antics. Typically I apply to ankles and knees, shoulders and hands 15 minutes before play. I get 3+ hours of pain free play. Just recently I started using a mixture of Sativa Extract (sold in 1g dispensing syringes) and DMSO on my sun scarred arms, face and legs (I am 62). I am excited that after less than a week how the patches and pre-cancers are begging to slough and my skin is starting to feel more supple and smooth. If anyone has any experience in this area please let me know. Thanks.

    Liked by 1 person

  3. Since it’s been a long time I don’t know if I’ll get an answer but figured I’d try. Can anyone tell me the amount how much of the salve is made using the recipe above? Can it simply be halved or quartered?


      • Great. I sure will. I’m searching around for best salve to make on my own. There are soooo many variations. Recently been reading more about DMSO and it sounds like it’s a must considering my problem is radiating pain from a nerve in my back. I know nothing will help the bad nerve but it may help with the radiating pain in the areas surrounding it. Since I’ve got you on the horn here, a couple questions if I may. Have uyou tried anything other than coconut oil. I’ve always used it for my own edibles but have read recently that grape seed and a couple others are even better. I’ve also read if you use coconut oil not to use the odorless type. Have you tried any additional herbs that are good for inflammation etc in addition to the arnica or do you think they are necessary? Have you used any essential oils? What about squeezing some RSO or distillate in the recipe? Anybody tried that? Thanks for listening!


        • Oh thanks for these questions Karl, yes there are countless variations and grapeseed does does like a good one. Nothing magical about coconut oil in this formulation.

          I recently made a pain-begone mixture and put it into roller ball dispensers: equal parts DMSO, arnica oil (organic from Etsy), and cannabis oil (in coconut oil) – and I wouldn’t say the nerve can’t be healed. In fact I’m trying to heal my spinal cord injury and science shows that CBD alone can repair the nerves!!


        • Oh and I also used Gotu Kola in the roll-on mixture (you can get those special bottle for roll-on on Amazon). I got powdered organic Gotu kola and put it in 2 parts oil of choice for 1.5 months, shaking daily (called macerated oil)


        • Oh and you can simply mix your cannabis oil/butter with equal part DMSO. You could probably use 5% DMSO and get a great result – it’s powerful.

          As for RSO, I’d let it sit in a little puddle of DMSO until it’s completely dispersed.


  4. Thanks Mr Admin. I feel like I’ve hit the mother lode. Just tell me to go away when I become a pest! I’m getting close to getting started and you’ve been of great help. I really appreciate your responses. I really like your formula. No long drawn out processes and essential oils and other additives like so many others I’ve read. I’ve made capsules many times before so I’ve got a good handle on oil although I use a different method.

    Are you using the DMSO cream or gel or liquid? What’s the viscosity like in your final product? How long does it take to dry and is it odorless? It’s not a small spot I’m talking. I’m hoping to dull lumbar pain that’s in about a 5”x5” area.

    My plan is to make a small amount using your formula verbatim and then make another with a distillate added and compare. Aside from not being as thick as RSO I can sometimes get distillate at BOGO. I also plan on using pre-ground flower which I never buy but I’m thinking may be fine for this purpose. Especially for testing purposes and considering a flash sale today for $5.75/gram. That’s a great deal. The top of the line flower here when on sale is around $10/ gram and next down about $8. (I’m not a fan of pre-ground flower. I’m even a confused grind-er. Sometimes I only use scissors.) My thought is that the dispensaries are selling their trash. Well, that’s a little harsh but I do feel like the machines they put it through scrapes most calyxes and trichromes off keeps so they can keep the kief to make other products and then leaves an inferior product behind. But I’m going to test it before using it of course.

    My goal is 2-fold. One is that the only salve we have here is weak and costs $40 for 2 ounces with 250 mg THC per jar (I have no idea what that means.) So I need to produce something cheaper. And next I need to produce something stronger because it’s moderate at best and doesn’t last very long.

    Thanks for listening! And for providing this great place to share ideas. I’m going to start gathering the materials and get started in the next few days.


    • No worries! I’m happy to throw ideas back and forth. Getting a good cannabis extract is number one, as you’re aware. I’m not well versed in dispensaries, but for some reason I’m inclined to believe starting with RSO and then melting it into an oil (melting = using DMSO to break it down) with viscosity you can use topically.
      If you’re just wanting to treat your own 5” square patch, I would think using an RSO/DMSO blend would be perfect. It would be very watery. Simply wait 20 minutes and wipe off the remainder if you need to.
      If you’re wanting to make something fancier like a balm, perhaps because it won’t rub off on clothes, I have to admit in haven’t tried this yet with DMSO.
      If you’re wanting to make a product to sell, I’m afraid I don’t have much more info at this time since I haven’t really explored this yet, my cannabis/DMSO mixtures have been super simple.
      Did this help? Other questions?


    • ON SECOND THOUGHT – consider that anything you put with DMSO is going straight to your bloodstream. RSO is extracted with stuff you wouldn’t want in your bloodstream. Can you find ‘clean’ RSO?


      • Oh yes! Helped a lot. I think your assessment is brilliant. I didn’t think about the RSO extraction and considering my plan to use with DMSO on a fairly large area I can see your concern. I’ve read up on it and still am not sure about it. But people do ingest it and then it enters the bloodstream. How does that differ from entering the bloodstream transdermally? Is it that someone could literally overdose/get ill from the combination?

        This is strictly for myself. Yes I want something not real greasy/wet. Definitely more like a balm. A consistency of a man’s light hair gel as opposed to like your doing with the roller ball. Something I can rub in the area then then let it soak in and be dry in 15-20 mins. Any pain relief between 25-50% for 3-5 hours would be miraculous. That’s the plan anyway.
        Now that you’ve given the caution about using RSO thank you, I’m going to forego that experiment. Perhaps I need to just go forward with the formula you’ve got posted and try it. But I’ve had no success with anything so I feel like this is going to have to be really strong to not be an exercise in futility. Nothing from opioids to a variety of other drugs and injections have ever done anything. Cannabis gives me only slight pain relief no matter the method.

        I wonder about distillate? I know a little about the difference between it and RSO but will have to do some reading as far as extraction methods which I’m going to do right now because my wife’s on the couch snoring anyway. (Really. Bloody. Loud.)


        • You could try extracting cannabinoids using just the dried plant and DMSO as the solvent! We may have just invented something!!

          (I’ll reply more later, but bottom line is you need a very clean extract. Eating it goes through the digestive tract which isn’t synonymous with using DMSO topically, as the latter is more akin to an IV – straight into the bloodstream.)


        • Interesting read:

          In general, cannabinoids are poorly water-soluble but highly soluble in lipids. Because of their poor water-solubility, they cannot be used directly to treat cells and measure their potential pharmacological effects. A common approach of their post-processing to enable such testing is to dissolve them in DMSO. By doing this, we cannot avoid the fact that this dissolution may alter the composition of crude extracts. Effects governing the composition of the resulting “secondary” extracts (DMSO solutions) are multifold.!po=6.91489


  5. I’m not sure which I’m more impressed with, your knowledge of DMSO, your familiarity with all things cannabis or your willingness to be so incredibly helpful.

    Those are great reads indeed. The one from Dr Segura is fascinating. I’ve been down the proverbial rabbit hole about DMSO as well as extractions since your last message. It never crossed my mind about how the DMSO could affect the extraction chemicals possibly making them toxic. It sound like you might’ve saved me from getting ill or worse. I would’ve never thought that in a million years.

    Your question is quite valid. What WOULD happen if I tried the DMSO alone? Would I get any relief? I’m certainly going to give it a try. I didn’t even know about before 2-3 weeks ago so I have to try it just to see. If it did anything I’d be thrilled because as I’m sure you know sometimes hope runs slim.

    I haven’t gotten DMSO yet. Do you use the gel? And which? 70% DMSO and 30% aloe? Or 70% and 30% distilled water? Or 90% and 10% water? Do you use a particular brand you like?

    Thanks again. Can’t wait to hear about your experiment!


    • Karl, that was such an incredibly nice thing to say ~ feels like an early Christmas present for me!

      Here is the DMSO I have: DMSO Low Odor in Glass 8 oz…

      If you want to dilute it, go for it. I hear that if the 99.99% causes too much discomfort (itching and burning for a few minutes) you can simply spray the area with distilled water!

      As for the science regarding DMSO and cannabis, saying it “could” have this or that effect means nothing more than pointing scientists in a certain direction for further study. It doesn’t mean there’s any indication that it is dangerous. That type of research paper has to point out all the variables, those they explore and those left to explore. The mixture of substances could just as easily be the next miracle – and let me share my knee jerk reaction:
      I doubt there is any danger and I believe that as helpful as cannabinoids are, using DMSO with them will only increase the miraculous healing power of cannabis.

      There are stores in the US that sell DMSO/CBD balms, it is common. I think we’d have heard something by now if it was causing problems.
      Also my best friend who is 84 uses it nightly to heal dementia – because it crosses the blood brain barrier, she rubs a mixture into her scalp every night with herbs known to heal the brain: cannabis, Gotu kola, Bacopa and something else Im forgetting. It has made her thinning hair now ridiculously thick ~ she can barely get a comb through it!

      I’ll let you know about the experiment, it will probably be just after Christmas ~ God bless!


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