Biochemist Dennis Hill, who cured his stage 3 prostate cancer with Cannabis oil, explains how it works


This article was recently mentioned in the Metro Times Detroit

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How Cannabinoids Kill Cancer – Dennis Hill

Update from Dennis Hill (2.28.13):

  • My progress is good. Asked my doctor the meaning of my last three PSAs. He said: The PSA has not risen over 2.4 in nine months, we can presume the cancer is in remission. Music to my ears. Cannabinoid extract wins again. Huzzah!

Previous update (12.8.12):

  • After six months using cannabis extract, a prostate biopsy confirmed the cancer was gone, in February 2010. Twenty months later, biopsy showed cancer had returned. I have reinstated cannabis extract and PSA is declining. I expect the cancer to be gone soon, just as it did previously.

On the need to decarboxylate medicine:

  • “My co-op hash oil had not been decarboxylated. THCA does not fit the CB-1 receptor that is required to send seramide to the work of apoptosis.” (This is why the cancer made a reappearance)
    How to decarboxylate

Retrospective on Cannabis and Cancer – Dennis Hill

Three years ago, after a prostate biopsy, I was given the diagnosis of aggressive Stage III adenocarcinoma. I didn’t know what to do. The urologist made appointments for me to start radiation, and maybe chemo. Then a friend told me cannabis cures cancer. It just so happened that the first human trials of cannabis treatment of astrocytomas (inoperable brain cancer), were published with encouraging results. So I decided; rather than die from the medical treatment, I would do the cannabis cure. Now… where to get some. There was no dispensary in the area, but a friend made me cannabis butter, so I took that, up to tolerance. In three months the primary cancer was gone, only minor metastatic lesions were left. At that point I found a supplier for Rick Simpson oil and killed off the metastases in the next three months. Now I just take a maintenance dose of locally produced hash oil that is 1:1 THC:CBD with about a 30% potency. This will certainly keep me clear of cancer, anywhere, for ever.
My point in telling this story is the fact that in the face of advanced aggressive cancer, all I had was very weak cannabutter, but it was enough to eliminate the primary tumor. Now there are strains of 95% THC. But is this necessary? If you have cancer and want to pursue the cannabis treatment, any at all will be good. More important than extreme potency, is balance between THC and CBD. If you can get high potency, great. If not, common potencies will work perfectly.
Finally, if you choose cannabinoid treatment, start small, then increase dosage as rapidly as tolerable. To kill cancer you have to hit it hard, be conscientious about your treatment. Cannabis does no harm to the body, it is a metabolic support for the immune system.

Summary:

Here are the basics, based on my own experience with cancer and cannabis oil extract.
  • Get Rick Simpson formula oil; including the important decarboxylation step to convert THCA to THC.
  • If possible, use 1:1 THC:CBD, as THC kills the cancer, CBD kills the cancer’s ability to metastasize.
  • Take as much as possible; the way to kill cancer is to hit it very hard. Start very small to acclimate to the oil properties, then keep increasing the dose as tolerable.
  • Take a large dose before bed, then a lighter dose during the day, to keep the pressure on the cancer.

This is how I managed my prostate cancer to have a successful resolution. ~ Dennis Hill (4.11.13)

~~~

From Cannabis Nation Radio

  • Read Dennis Hill’s Curing Cancer With Cannabis Extract: a Journal
  • Learn to make Cannabis Oil
  • Notes: Cannabis and Marijuana oil/extract are terms used interchangeably to refer to Rick Simpson’s “Hemp Oil” (“RSO”). In Canada, where Rick is from, Hemp refers to cannabis. In the US, Hemp refers to the non-THC bearing plant used for textiles etc.; “Hemp Seed Oil” is sold legally, but is not the same as Rick’s high-THC “Hemp Oil”.

From Cannabis Nation Radio Biochemist Dennis Hill graduated from the University of Houston and did his Graduate Work at Baylor Medical School. Dennis worked as a Cancer Researcher at the MD Anderson Cancer Center in Houston. When Dennis was diagnosed with advanced stage prostate cancer, which had metastasized to other parts of his body, he started researching. Since Dennis has a family history of prostate cancer, and he often witnessed ineffective results while working in cancer research, he felt a new approach was in order.

After researching possible alternatives Dennis ran across information about Rick Simpson using cannabis concentrate, which is an extract of the essential oil which is extracted from marijuana and contains cannabinoids. Simpson was using the oil to treat a wide variety of illness, including cancer. The more Dennis researched, the more he understood how cannabis worked on cancer. He has included 2 papers for the review of anyone interested that go into the science of how cannabis kills cancer. He was determined to give it a try, and decided to tell his doctor that he would be using cannabis concentrate alone for his treatment. He did not want to risk more damage to his body from chemo, so he chose to start the cannabis oil regime without any other treatment.

Dennis is educated, with a sound background in science, and a background in the cancer industry. He stated that the Cannabis Oil killed the cancer, and he is now cancer free. He never underwent any of the standard treatment ie chemo, or radiation. He maintained a healthy diet, and exercise as part of his healing and after care. Dennis worked two jobs while he was treating himself, and never experienced any of the side effects typically associated with standard cancer treatments. He administered 1 tiny dose of the cannabis oil in the AM, and 1 tiny dose of the cannabis oil in the pm, just as Rick Simpson suggests.

Here, Dennis Hill explains the inner workings of cancer death-by-Cannabinoids:

Cannabinoids and cancer

Cancer-specific Cytotoxicity of Cannabinoids

By Dennis Hill (reprinted with permission)

First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness.

In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “Sphingolipid Rheostat.” If ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell will be strong in its vitality.

Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.

The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.

Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren’t enough, ceramide disrupts the cellular lysosome, the cell’s digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.

The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of cannabinoid extract, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.

How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for it’s matched exocannabinoid activator.

This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. This is the primary control system that maintains homeostasis; our well being.

Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids perform the same function. It helps the body in the most natural way possible.

To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it’s much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites.Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).

It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.

Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body’s immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.

In 2006, researchers in Italy showed the specifics of how Cannabidiol (CBD) kills cancer. When CBD pairs with the cancer cell receptor CB-2 it stimulates what is known as the Caspase Cascade, that kills the cancer cell. First, let’s look at the nomenclature, then to how Caspase kills cancer. Caspase in an aggregate term for all cysteine-aspartic proteases. The protease part of this term comes from prote (from protein) and -ase (destroyer). Thus the caspases break down proteins and peptides in the moribund cell. This becomes obvious when we see caspase-3 referred to as the executioner. In the pathway of apoptosis, other caspases are brought in to complete the cascade.9

Even when the cascade is done and all the cancer is gone, CBD is still at work healing the body. Its pairing at CB-2 also shuts down the Id-1 gene; a gene that allows metastatic lesions to form. Fundamentally this means that treatment with cannabinoids not only kills cancer through numerous simultaneous pathways, but prevents metastasis. What’s not to like. One researcher says this: CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic carcinoma leading to the down-regulation of tumor aggressiveness.10

This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.

Bibliography
1. http://cancerres.aacrjournals.org/content/65/5/1635.abstract
Sami Sarfaraz, Farrukh Afaq, Vaqar M. Adhami, and Hasan Mukhtar + Author Affiliations. Department of Dermatology, University of Wisconsin, Madison, Wisconsin
2. http://www.ncbi.nlm.nih.gov/sites/pubmed
J Neuroimmunol. 2007 Mar;184(1-2):127-35. Epub 2006 Dec 28.
Immune control by endocannabinoids – new mechanisms of neuroprotection? Ullrich O, Merker K, Timm J, Tauber S.
Institute of Immunology, Medical Faculty, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. oliver.ullrich@medizine.uni-magdeburg.de
3. http://en.wikipedia.org/wiki/Endocannabinoid_system
Endocannabinoid synthesis & release.
4. http://en.wikipedia.org/wiki/Cannabinoids
Cannabinoid receptor type 1.
5. http://www3.interscience.wiley.com/journal/121381780/abstract?CRETRY=1&SRETRY=0
Journal of Neurochemistry, Volume 104 Issue 4, Pages 1091 – 1100
Published Online: 18 Aug 2008
6. http://leavesofgrass.info/info/Non-Psychoactive-Cannabinoids.pdf
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
Angelo A. Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo, and Raphael Mechoulam. Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy. Institute of Biomolecular Chemistry, National Research Council, Pozzuoli (NA), Italy. Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem, Israel, Endocannabinoid Research Group, Italy
7. http://sciencenews.org/view/feature/id/59872/title/Not_just_a_high
Scientists test medicinal marijuana against MS, inflammation and cancer
By Nathan Seppa June 19th, 2010; Vol.177 #13 (p. 16)
8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766198/
NIH Public Access:
A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death
Tarek A. Taha, Thomas D. Mullen, and Lina M. Obeid
Division of General Internal Medicine, Ralph H. Johnson Veterans Administration Hospital, Charleston, South Carolina 29401; and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425
Corresponding author: Lina M. Obeid, M.D., Department of Medicine, Medical University of South Carolina, 114 Doughty St., P.O.Box 250779, Charleston, South Carolina 29425. E-mail: obeidl@musc.edu
9. P. Massi, A. Vaccani, S. Bianchessi, B. Costa, P. Macchi, D. Parolaro
Cellular and Molecular Life Sciences CMLS
September 2006, Volume 63, Issue 17, pp 2057-2066
http://link.springer.com/article/10.1007%2Fs00018-006-6156-x?LI=true
10. Mol Cancer Ther. 2007 Nov;6(11):2921-7.
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.
McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez PY.
California Pacific Medical Center, Research Institute, 475 Brannan Street, San Francisco, CA 94107, USA. mcallis@cpmcri.org
http://www.ncbi.nlm.nih.gov/pubmed/18025276

The Human Endocannabinoid System Meets the Inflammatory Cytokine Cascade

By: Dennis Hill
The Endocannabinoid System (ECS) started revealing itself to researchers in the 1940s and by the late ’60s the basic structure and functionality had been laid out. Today we know the ECS is a comprehensive system of biochemical modulators that maintain homeostasis in all body systems including the central and peripheral nervous systems, all organ systems, somatic tissues, and all metabolic biochemical systems, including the immune system.

This homeostatic matrix is not a recent evolutionary twist just for humans; we Find the Endo cannabinoid System in every chordate creature for the last 500 million years. It is a fully mature biochemical technology that has maintained health and metabolic balance for most of the history of life itself.

The two major interactive systems within the ECS are (1) the cannabinoid receptors that we find on all cell surfaces and neurological junctions and (2) the endocannabinoids that hit the receptors to trigger various metabolic processes. Looking at a cannabinoid receptor distribution map we see that CB1 receptors, that are most sensitive to anandamide, are found in the brain, spinal nerves, and peripheral nerves. CB2 receptors preferred by 2-arachidonoylglycerol (2-AG) are found largely in the immune system, primarily the spleen. A mix of CB1 and CB2 receptors are found throughout the rest of the body including the skeletal system. And yes, 2-AG or CBD will grow new trabecular bone.1 It is also useful to note that both anandamide and 2-AG can activate either CB1 or CB2 receptors.

The nature of the endocannabinoids are functionally much like neurotransmitters, but structurally are eicosanoids in the family of signaling sphingolipids. These signaling cannabinoids keep track of metabolic systems all over the body. This information is shared with the nervous system and the immune system so that any imbalance is attended to. If the body is in chronic disease or emotional stress, the immune system can fall behind and lose control of compromised systems. It is here that phytocannabinoids can pitch in to support the stressed body in a return to health. The cannabis plant provides analogues of the body’s primary signaling cannabinoids. Tetrahydrocannabinol (THC) is mimetic to anandamide, and cannabidiol (CBD) is mimetic to 2-AG, and has the same affinity to CB1 and CB2 receptors; providing the body with additional support for the immune and endocannabinoid systems.

Phytocannabinoids supercharge the body’s own Endocannabinoid System by amping up the response to demand from the immune signaling system in two modes of intervention: one, of course, is in bonding with the cannabinoid receptors; the other is in regulation of innumerable physiological processes, such as cannabinoid’s powerful neuroprotective and anti-inflammatory actions, quite apart from the receptor system. It is interesting to note here that the phytocannabinoids and related endocannabinoids are functionally similar, but structurally different. As noted above, anandamide and 2-AG are eicosanoids while THC and CBD are tricyclic terpenes.

Let us look more closely at the two primary therapeutic cannabinoids, THC and CBD. The National Institutes of Health tell us that THC is the best known because of its signature psycho- tropic effect. This government report shows THC to be effective as an anti-cancer treatment, an appetite stimulant, analgesic, antiemetic, anxiolytic, and sedative.2

CBD (cannabidiol) is a metabolic sibling of THC, in that they are alike in many ways but are also different in important properties. First we see that CBD has no psychotropic effects and there are few CB2 receptors in the brain and peripheral nerves. There appears to be a broader therapeutic profile associated with CBD, which is listed here:

One of the most important health benefits of cannabinoids is their anti-inflammatory property. In this, they are strong modulators of the inflammatory cytokine cascade. Numerous disease states arise out of chronic inflammation; such as, depression, dementias including Alzheimer’s, cancer, arthritis and other autoimmune disorders, viral infection, HIV, brain injury, etc.

Inflammatory cytokines can be activated by oxidative stress and disease states. Cannabinoids, being immunomodulators interrupt the cytokine inflammatory cascade so that local inflammation does not result in tissue pathology. Thus we are spared morbid or terminal illnesses.4
If our own endocannabinoid system can maintain metabolic homeostasis and even cure serious disease, why are we plagued by illness? We know that the body produces only small amounts of anandamide and 2-AG; enough to maintain the body but not enough to overcome chronic stress, illness, injury, or malnutrition. Cannabis is the only plant we know of that produces phyto- cannabinoids that mimic our own endocannabinoids. One of the great benefits of this mimetic medicine is that cannabinoids are essentially natural to our biology and do no harm to our tissues and systems.

It is well known that most diseases of aging are inflammatory in origin, thus making cannabis the best anti-aging supplement we could take to avoid arthritis, dementia, hypertension, diabetes, osteoporosis, and cancer. This is our key to good health and long life.

Since it is such an important attribute, as well as being independent of the cannabinoid receptor system, let’s look a little deeper into the ability of cannabinoids to inhibit the inflammatory cytokine cascade. Inflammation is good for us, a little here, a little there; it brings T-cells and macrophages to infection sites. This is good. However, chronic inflammation can cause serious illness and death. How do phytocannabinoids rescue us from dreaded infirmities? When the call comes in to the immune system to send troops, the First thing to happen is that the immune system signals glial cells to produce cytokines. Once this cat is out of the bag, the process can go one of two ways.

A) Killer cells clean up the infection and all is well.

B) Cytokines can stimulate more cytokine production and cause many more cytokine receptors to awaken. Unchecked, this becomes a cytokine storm showing symptoms of swelling, redness, fatigue, and nausea; even death.

Phytocannabinoids have the ability to suppress this inflammatory cytokine cascade by inhibiting glial cell production of the cytokines interferon or interleukin. Here we see the seeds of chronic inflammation dissolved by the modulation process of cannabinoids bringing homeostasis to systems out of balance. This is a good example of how cannabinoids normalize biological processes all throughout the body and allows us to keep that glow of well-being through a long and happy lifetime. (Bibliography)

Dennis Hill

Dr Bob Melemede explains further

 

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12 thoughts on “Biochemist Dennis Hill, who cured his stage 3 prostate cancer with Cannabis oil, explains how it works

    • It’s actually not a tincture, which is alcohol based and not as strong – it’s an oil. Ask for “Rick Simpson oil” at your local dispensary.

      Like

    • I have been informed I have stage three prostate cancer, where can I find someone to help me with obtaining and administrating the proper doses.

      Like

      • If you live in a cannabis legal state, call MediCann 1-866-632-6627 for a physician to evaluate your condition and make recommendations. ~Dennis

        Like

  1. ScienceDaily: Marijuana News

    Synthetic drugs: evidence that they can cause cancer

    Posted: 16 Apr 2015 05:37 AM PDT
    Almost weekly, a new synthetic psychoactive drug comes onto the market that can be ordered legally and easily, for example as an incense blend, via the Internet. Synthetic cannabinoids are difficult to identify chemically and the possible unwanted toxic effects that can occur following their consumption have so far barely been investigated. As part of the international EU project “SPICE II Plus”, researchers have now also found evidence that synthetic substances damage the DNA of human cells and can therefore possibly have cancer-causing effects.

    Major occupational health groups publish guidance for employers on the impact of marijuana in the workplace

    Posted: 13 Apr 2015 06:31 PM PDT
    Experts have published guidance for employers aimed at helping them better understand the implications of marijuana use on the workforce as attitudes toward marijuana and laws restricting it continue to change. The guidance paper summarizes current evidence regarding marijuana consumption; discusses possible side effects, including temporary impairment as it relates to the workplace; reviews existing federal and state laws that impact employers; and suggests various strategies available for monitoring marijuana use among employees.
    You are subscribed to email updates from Marijuana News — ScienceDaily

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  2. Alberta mom denied marijuana prescription for daughter turns to Ontario clinic

    SHERYL UBELACKER, THE CANADIAN PRESS 09.14.2015

    TORONTO – An Alberta mother whose daughter has severe epilepsy has travelled to Ontario for a medical marijuana prescription after the girl’s doctor said he was no longer allowed to provide permission to purchase the product.

    In 2013, Sarah Wilkinson had started extracting cannabis oil from dried marijuana — purchased from a licensed grower with a prescription from a neurologist at Alberta Children’s Hospital — to prevent life-threatening seizures in her eight-year-old daughter Mia.

    But in July, the physician declined to renew the prescription because of a hospital policy based on the position of Alberta Health Services, the provincial health authority, which does not support the use of medical marijuana for pediatric patients with epilepsy.

    Wilkinson said the cannabis oil is the only therapy that has worked to stop Mia’s seizures, caused by a rare type of epilepsy called Ohtahara syndrome.

    Despite taking 30 to 40 anti-convulsive pills daily, Mia would suffer up to 100 seizures a day, said her mother. But since starting daily doses of oral cannabis oil 19 months ago, she has not had a single seizure.

    On Monday, Mia was seen by a doctor at the Canadian Cannabis Clinic in St. Catharines, Ont., and left with a prescription for dried marijuana, which her mother can fill from a federally licensed producer after returning to their Airdrie, Alta., home.

    “It’s a big relief. I don’t have to worry about when I run out of her meds,” said her mother, who had been worried about her dwindling supply of medical-grade marijuana purchased with the initial prescription.

    Wilkinson said she turned to cannabis because nothing else was helping her child, whose seizures could be so severe she would stop breathing and have to be resuscitated and rushed to hospital.

    “I really took a big leap of faith with that,” she said of the cannabis oil, adding that within 24 hours of the first dose, Mia’s seizures had completely stopped.

    Without the treatment, “we would have waited for the next big seizure and she would have died. There’s not a really nice way to say that.

    “Now, we can all breathe.”

    For Mia, tetrahydrocannabinol, or THC, appears to be the ingredient in marijuana that controls her seizures, while others with different forms of epilepsy benefit from another component of the plant called cannabidiol, or CBD.

    Pharmacologist-toxicologist McIntyre Burnham, co-director of the Epilepsy Research Program of the Ontario Brain Institute in Toronto, said about 30 per cent of people with seizures don’t respond to any anti-convulsive medications.

    His program plans to seek Health Canada approval for a clinical trial in adults of a cannabidiol in capsule form being developed by Canadian medical marijuana producer Tilray, which he hopes will start in about a year.

    While THC does stop seizures in some people, it’s also the active ingredient in marijuana that “makes you high,” said Burnham, whereas CBD does not.

    Researchers agree clinical trials are needed to determine if the various strains and extracts of marijuana can benefit patients with a variety of conditions, and cannabidiol appears “quite promising” for epilepsy, he said.

    But “people are thinking it’s a wonder drug. I think it’s too early to say that … It’s not going to be for everyone. It will help some people and not help others.”

    Kunvar Mudhar does believe CBD is a wonder drug.

    A year ago, she started giving cannabis oil high in CBD to her son Zen, who has intractable epilepsy related to cerebral palsy that is resistant to all anti-convulsive medications.

    As a baby, he had been put on a special diet, which reduced the number and severity of his seizures — but he was still experiencing about 150 a day.

    “The first night I gave him the first dose, we started off very low,” said Mudhar of Mississauga, Ont., who makes cannabis oil from dried marijuana purchased through a doctor’s prescription.

    Within a day, the number of Zen’s seizures dropped to about 30, and with a slight increase in the dose, they disappeared for months.

    Mudhar had been treating Zen, now 7, with an oil high in CBD and low in THC, but she also had on hand an oil extract she’d prepared with a two-to-one ratio of CBD to THC.

    One night in February, her son suffered a grand mal seizure, despite the daily cannabis therapy.

    “His body was jerking. He started to turn grey-blue,” she said. “At that point, I had nothing else to give him. I had already called the paramedics and was waiting for them to come.

    “The last thing I did was grab that (higher THC-dose) oil and rub it on his gums — and the seizure stopped.”

    Mudhar said she would have been happy if the cannabis oil had just reduced his seizures by a significant amount.

    “But this is amazing. To me, this is more than a miracle that Zen has seizure-free days.”

    — Follow @SherylUbelacker on Twitter.

    Note to readers: This is a corrected story. An earlier version had the wrong first name for Sarah Wilkinson.

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  3. Hi Dennis,
    I have some CBD oil and THC tincture (I couldn’t get THC oil). Will they work together? Should I take the THC tincture one hour after the CBD oil so they can work together and the CBD can moderate the psycho effect of the THC, or is this timing detail unimportant?
    Neil

    Like

  4. This question is on cannabinoid-resistant cancer.

    My grandpa has been a stage-4 prostate cancer patient. (84 yrs old)

    In the first weeks of his cannabis treatment, his PSA levels fell from 120 to 30 (in just 25 days) !!!!!!!

    But, due to mistakes made by me later in dosage (I stopped giving cannabis for 30 days, due to another medical problem he had), cancer has become cannabinoid resistant.
    (and PSA has been rising since 8 months and it is now 180)
    Please suggest something…

    It looks like his cancer has become cannabinoid resistant.
    It has perhaps mutated to find a way around the cannabis anti-cancer effect.

    His current dosage is: 1/2 rice grain..4 times day
    I know, I am increasing it gradually (my bad, that I could not reach the optimum level in time)..
    Despite the gradual increase I am doing, I am still seeing that the PSA is rising fast.
    40 points in 20 days.
    And I feel that even after increasing dosage, it may not work very well, as it has become cannabinoid resistant.

    What can I do , in this stage?

    1) Can I make it sensitive to cannabis by cleansing the cannabinoid receptors. How to cleanse?
    2) Currently I am using a cannabis-oil with 85% THC
    3) Shall I include synthetic CBD (example hu-331), in his diet
    4) SHould I introduce hihg concentration CBD oils
    5) Vitamin B17?
    6) GcMAF Bravo Probiotic curd

    He is only on hormone therapy. No chemo done ever.
    Also, at the time at which cancer became cannabinoid-resistant, we had given him ibandronic-acid / zoledranic acid infusions. (Cud this be the reason for ineffectiveness)…
    What can I do, please guide?

    Thanks

    Like

  5. This question is on cannabinoid-resistant cancer.

    My grandpa has been a stage-4 prostate cancer patient.

    In the first weeks of his cannabis treatment, his PSA levels fell from 120 to 30 (in just 25 days) !!!!!!!

    But, due to mistakes made by me later in dosage (I stopped giving cannabis for 30 days, due to another medical problem he had), cancer has become cannabinoid resistant.
    (and PSA has been rising since 8 months and it is now 180)
    Please suggest something…

    It looks like his cancer has become cannabinoid resistant.
    It has perhaps mutated to find a way around the cannabis anti-cancer effect.

    His current dosage is: 1/2 rice grain..4 times day
    I know, I am increasing it gradually (my bad, that I could not reach the optimum level in time)..
    Despite the gradual increase I am doing, I am still seeing that the PSA is rising fast.
    40 points in 20 days.
    And I feel that even after increasing dosage, it may not work very well, as it has become cannabinoid resistant.

    What can I do , in this stage?

    1) Can I make it sensitive to cannabis by cleansing the cannabinoid receptors. How to cleanse?
    2) Currently I am using a cannabis-oil with 85% THC
    3) Shall I include synthetic CBD (example hu-331), in his diet
    4) SHould I introduce hihg concentration CBD oils
    5) Vitamin B17?
    6) GcMAF Bravo Probiotic curd

    He is only on hormone therapy. No chemo done ever.
    Also, at the time at which cancer became cannabinoid-resistant, we had given him ibandronic-acid / zoledranic acid infusions. (Cud this be the reason for ineffectiveness)…
    What can I do, please guide?

    Thanks

    Like

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