Dennis Hill: How Cannabinoids Kill Cancer

See also: Biochemist Dennis Hill, who cured his stage 4 prostate cancer with Cannabis Oil, explains how it works

This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.

~Dennis Hill

How It Works (Abstract)

There is a plentiful supply of research articles and personal testaments that show the efficacy of cannabis effecting cancer remission. However, only a few point to the mechanism by which the cancer cells die. To understand this better we need to know what metabolic processes provide life to the cells.

There are two structures in most cells that sustains life; one is the mitochondria, and the other is the endoplasmic reticulum. The mitochondria primarily produces adenosine triphosphate (ATP) that provides the necessary energy. The endoplasmic reticulum (ER) is a loosely bound envelope around the cell nucleus that synthesizes metabolites and proteins directed by the nuclear DNA that nourish and sustain the cell.

Let us look first at tetrahydrocannabinol (THC) and observe that THC is a natural fit for the CB1 cannabinoid receptor on the cancer cell surface. When THC hits the receptor, the cell generates ceramide that disrupts the mitochondria, closing off energy for the cell.

Disruption of the mitochondria releases cytochrome c and reactive oxygen species into the cytosol, hastening cell death. It is notable that this process is specific to cancer cells. Healthy cells have no reaction to THC at the CB1 receptor. The increase in ceramide also disrupts calcium metabolism in the mitochondria, completing the demise to cell death.

The other cannabinoid we know is effective in killing cancer cells is cannabidiol (CBD). The primary job of CBD in the cancer cell is to disrupt the endoplasmic reticulum through wrecking of the calcium metabolism, pushing calcium into the cytosol. This always results in cell death. Another pathway for CBD to effect cancer cell death is the Caspase Cascade, which breaks down proteins and peptides in the cell. When this happens the cell cannot survive. Again, these processes are specific to cancer cells, no normal cells are affected.

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Cannabis and the brain

In Progressives Should Just Say No to Legalizing Drugs (US News), Carrie Wofford writes, “There’s a good reason drugs are illegal: They’re dangerous”.

She explains:

Drugs kill. They turn talented, intelligent people into impulsive animals. They destroy marriages. They deprive children of emotionally healthy parents. There’s a good reason drugs are illegal: They’re dangerous. Products that kill do not belong on drugstore shelves.

After reminding the reader of Philip Seymour Hoffman’s tragic overdose (whose heroin addiction was the result of legal drugs prescribed to him for pain), Wofford brings Cannabis into the argument by citing its deleterious effects on brain tissue: Continue reading

NBC News: Marijuana Compound CBD Fights Cancer; Human Trials Next

“If this plant were discovered in the Amazon today, scientists would be falling all over each other to be the first to bring it to market” ~ Dr. Donald Abrams, chief of oncology at the University of California San Francisco

English: 2D structure of cannabidiol (CBD)

English: 2D structure of cannabidiol (CBD) (Photo credit: Wikipedia)

David McNew/Getty Images

from NBC Bay Area (Sept 19, 2012)

The “medical” bit of medical marijuana may be legitimate after all: Turns out a component of cannabis fights cancer, according to research.

Scientists at California Pacific Medical Center found that cannabidiol, or CBD, has the ability to “turn off” the DNA that causes “breast and other types of cancers” to metastasize, according to the San Francisco Chronicle.

“If this plant were discovered in the Amazon today, scientists would be falling all over each other to be the first to bring it to market,” said Dr. Donald Abrams, chief of oncology at the University of California San Francisco, which has also found science behind marijuana’s efficacy. Continue reading

Cannabinoid System in Neuroprotection, Raphael Mechoulam, PhD

Professor at Hebrew University in Jerusalem, Dr. Mechoulam describes the role of Cannabinoids as anti-inflammatory for arthritis, as neuroprotectant for brain injury and as a possible treatment for PTSD. Dr. Mechoulam first isolated THC in 1964.
Conference hosted by Patients Out of Time. DVDs are available.

Cannabis may prevent osteoporosis

X-ray generic

Scientists studied the impact of cannabis on the bones

Researchers looking at the effects of cannabis on bones have found its impact varies dramatically with age.

The study found that while the drug may reduce bone strength in the young, it could protect against osteoporosis, a weakening of the bones, in later life.
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Evolution and cannabis – human brain is hard-wired to experience marijuana’s highs

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Article written by Greg Campbell for Greenzone you are still wondering whether humans were intended to enjoy and benefit from marijuana’s main psychoactive ingredient, THC, pick up a copy of Michael Pollan’s bestseller “The Botany of Desire.” Pollan, a contributor to The New York Times, should be required reading for anyone weighing the pros and cons of marijuana’s booming new acceptance, both as a medicine and perhaps further down the line as a recreational drug. I stumbled across it while researching my own book on medical marijuana, and this is one of the best I’ve found explaining the drug’s affect on the human brain. Most fascinating to me is the revelation that the brain is pre-wired to accept cannabinoids, the active ingredients in cannabis of which THC is one. Just as the brain has receptor cells for endorphins, serotonin and other chemical compounds, so too are there cells specially designed to pair with cannabinoids to unlock certain mental functions.
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